Amsacrine Anticancer Drugs Oncology Pharmacology Physiotherapy

Amsacrine (Mutation-1)

In this article we will discuss Amsacrine (Mutation-1)

In this article, we will discuss Amsacrine (Mutation-1). So, let’s get started.

It inhibits DNA topoisomerase II enzymes: Amsacrine is a DNA topoisomerase II poison that has been shown to promote DNA cleavage, with a strong prefer-
ence for a site one base away from adenine (Marsh et al., 1996). Most of the mutational events reported in mammalian cells, including point mutations, chromosomal deletions and exchanges and aneuploidy, can be explained by this activity. Amsacrine does not inhibit bacterial topoisomerases and may not mutate bacterial cells by the same mechanism as mammalian cells.

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