Clinical practice guidelines shape oncology care worldwide. Major organizations such as NCCN, ASCO, and ESMO publish these documents regularly. Clinicians rely on them for diagnosis, treatment, and follow-up decisions. However, the quality of evidence that supports these recommendations varies. Therefore, systematic assessment becomes essential. Researchers apply two key tools for this purpose. AGREE II evaluates […]
Category: Oncology
Tumour heterogeneity describes genetic and molecular differences within a single tumour. Cancer cells in one mass often carry distinct mutations. Genomic profiling maps these differences in detail. Researchers use next-generation sequencing to analyse tumour DNA. They also apply single-cell sequencing to study individual cells. Multi-region sampling further reveals spatial variation across the tumour. As a […]
Study Reveals Gaps in Oncology Guideline Adherence Across Tertiary Cancer Centers Researchers examined adherence to oncology patient care guidelines in major tertiary cancer centers. They compared national standards from ICMR and NCI-India with international ones from ASCO, ESMO, and NCCN. The analysis focused on how closely doctors followed these guidelines. It also measured links to […]
PD-L1 expression shows clear heterogeneity across solid tumours. Researchers actively examine this variation. They measure its direct impact on immunotherapy results. Tumours express PD-L1 at different levels. Levels also change within the same tumour. Pathologists observe spatial differences. They further note temporal changes during treatment. Anatomical site strongly influences expression patterns. Lung cancers often display […]
Spatial and Temporal Analysis of Tobacco-Related Cancers in High-Burden Regions of India Tobacco-related cancers form a major public health challenge in India. These cancers include oral cavity, lung, esophagus, larynx, and pharynx malignancies. High-burden regions show clear geographic clustering and changing patterns over time. Several states report elevated incidence rates. The Northeast region consistently records […]
Role of Cancer-Associated Fibroblasts and Extracellular Matrix Remodeling in Promoting Therapy Resistance: Integrated Molecular and Histopathological Analysis Cancer-associated fibroblasts play a central role in the tumor microenvironment. These cells actively support tumor growth and progression. At the same time, they remodel the extracellular matrix. This remodeling creates physical and biochemical barriers that limit drug delivery. […]