Novel Biomarkers for Predicting Response to Checkpoint Inhibitors Checkpoint inhibitors have transformed cancer treatment. These drugs block proteins such as PD-1, PD-L1 and CTLA-4. They allow the immune system to attack tumor cells. However, only a portion of patients respond well. Therefore, researchers seek reliable biomarkers to identify likely responders before treatment begins. Current biomarkers […]
Category: Oncology
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Gastric Cancer Epidemiology
Gastric Cancer Epidemiology Gastric cancer remains a major global health concern. It shows wide variation in occurrence across regions. In addition, incidence rates differ sharply between high-risk and low-risk populations. Therefore, understanding its distribution helps guide prevention and screening efforts. East Asia records the highest rates of gastric cancer. Countries such as Japan, South Korea, […]
New Drug Therapies for Multiple Myeloma Multiple myeloma treatment continues to advance rapidly. New therapies now target the disease more precisely and produce deeper responses. As a result, options for both newly diagnosed and relapsed patients have expanded significantly. First, bispecific antibodies have transformed care. These drugs engage T cells to attack myeloma cells. Teclistamab […]
Bispecific T-cell Engagers in Hematologic Malignancies Bispecific T-cell engagers redirect the immune system against blood cancers. These antibodies bind a tumor antigen on one arm and CD3 on T cells on the other arm. The linkage forces T cells to kill malignant cells. As a result, the approach bypasses the need for prior antigen presentation […]
Personalized Neoantigen mRNA Vaccines Targeting Hard to Treat Cancers Cancer vaccines train the immune system to recognize and attack tumor cells. Neoantigen vaccines focus on unique mutations found only in a patient’s cancer. mRNA technology delivers instructions for these neoantigens, so the body produces them and generates a targeted immune response. Researchers are testing these […]
Multi-Cancer Early Detection (MCED) Blood Tests: Performance Limitations and Clinical Utility Multi-cancer early detection (MCED) blood tests aim to identify signals from multiple cancer types in a single sample. These tests primarily analyze cell-free DNA methylation patterns or other circulating biomarkers. Researchers and companies continue to evaluate their performance in large studies. However, questions remain […]