Monoclonal Gammopathy (MGUS) Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which plasma cells produce an abnormal protein. Doctors call this protein an M-protein or monoclonal protein. The condition does not usually cause symptoms. However, it can sometimes progress to a more serious disorder. How Doctors Detect MGUS Doctors often discover MGUS during […]
Infection-Associated Cancers Worldwide Certain infections raise the risk of cancer in specific organs. These infection-associated cancers account for a substantial share of cases globally. Viruses, bacteria, and parasites act as the main agents. Therefore, prevention of the underlying infection often reduces cancer risk later in life. Major Infectious Agents and Linked Cancers Human papillomavirus drives […]
Epidemiology of Leukemia Leukemia is a group of cancers that affect the blood and bone marrow. Epidemiological studies track its occurrence, distribution, and risk patterns across populations. These studies help identify high-risk groups and guide prevention and screening efforts. Leukemia ranks among the more common cancers in children and also affects adults of all ages. […]
New Drug Therapies for Multiple Myeloma Multiple myeloma treatment continues to advance rapidly. New therapies now target the disease more precisely and produce deeper responses. As a result, options for both newly diagnosed and relapsed patients have expanded significantly. First, bispecific antibodies have transformed care. These drugs engage T cells to attack myeloma cells. Teclistamab […]
Menin Inhibitors for KMT2A- and NPM1-Mutated AML Acute myeloid leukemia is not one disease. Some cases carry a KMT2A rearrangement. Others carry an NPM1 mutation. Both groups often depend on a protein called menin. New drugs try to block that dependence. KMT2A was once called MLL. When it fuses to a partner gene, it turns […]
Staphylococcal Toxin-Mediated Disease Staphylococcus aureus can injure the host without invading every tissue. Several of its diseases are driven by secreted toxins. The bacteria may stay at a limited site. The toxin then travels and produces the clinical picture. Superantigens are central to toxic shock. TSST-1 and some enterotoxins link MHC class II to T-cell […]