Oral cancer remains a major health concern in India. Tobacco use drives a large share of cases. Many patients reach hospitals only after the disease has advanced. Diagnostic delays play a critical role in this pattern. Patients often wait long before seeking care. They also face further delays after contacting the health system. As a […]
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Physiotherapist, Certified MFR therapist on a mission to provide one stop search destination for various diseases its symptoms,causes,diagnosis,treatment, physiotherapy management,rehabilitation with practical examples for aspiring physiotherapists,medical professionals and general public.
Neoadjuvant therapy aims to shrink tumors before surgery. However, residual disease often persists. These remaining cells can drive later relapse. Researchers therefore examine residual populations closely. Longitudinal multi-omics profiling tracks molecular changes over time. Scientists collect samples before treatment and after therapy. They then analyze DNA, RNA, proteins and epigenetic marks together. This integrated approach […]
PD-L1 expression shows clear heterogeneity across solid tumours. Researchers actively examine this variation. They measure its direct impact on immunotherapy results. Tumours express PD-L1 at different levels. Levels also change within the same tumour. Pathologists observe spatial differences. They further note temporal changes during treatment. Anatomical site strongly influences expression patterns. Lung cancers often display […]
Amyloid-Beta Oligomer Toxicity Mechanisms Amyloid-beta (Aβ) oligomers are widely regarded as the most toxic species in Alzheimer’s disease pathogenesis. Unlike mature amyloid plaques, soluble oligomers appear early, diffuse through tissue, and disrupt neuronal function at low concentrations. Researchers focus on these intermediate assemblies because they correlate more strongly with cognitive decline than plaque burden. 1. […]
Spatial and Temporal Analysis of Tobacco-Related Cancers in High-Burden Regions of India Tobacco-related cancers form a major public health challenge in India. These cancers include oral cavity, lung, esophagus, larynx, and pharynx malignancies. High-burden regions show clear geographic clustering and changing patterns over time. Several states report elevated incidence rates. The Northeast region consistently records […]
Role of Cancer-Associated Fibroblasts and Extracellular Matrix Remodeling in Promoting Therapy Resistance: Integrated Molecular and Histopathological Analysis Cancer-associated fibroblasts play a central role in the tumor microenvironment. These cells actively support tumor growth and progression. At the same time, they remodel the extracellular matrix. This remodeling creates physical and biochemical barriers that limit drug delivery. […]