In this article, we will discuss Rucaparib (Description). So, let’s get started. Rucaparib is a targeted cancer therapy belonging to the class of drugs known as PARP inhibitors. Here’s a brief description: Mechanism of Action: Rucaparib works by inhibiting the activity of poly (ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair. By blocking PARP, […]
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In this article, we will discuss Rucaparib (Uses). So, let’s get started. Rucaparib is a medication used in the treatment of certain types of cancer. Specifically, it is a poly ADP-ribose polymerase (PARP) inhibitor. Here are the main uses of Rucaparib: Ovarian Cancer: Rucaparib is approved for the maintenance treatment of recurrent ovarian cancer. It […]
Sulindac Protects Cardiac Myocytes Against Oxidative Damage The initial experiments were designed to determine whether sulindac could protect primary neonatal cardiac myocytes in culture against oxidative damage. The cardiac myocytes were exposed to hypoxia and reoxygenation to promote oxidative damage in the presence or absence of sulindac. Cell viability was then assayed by LDH release. […]
Thalidomide: News Australia’s prime minister Anthony Albanese has given a national apology to survivors of the thalidomide scandal and their families. “This apology takes in one of the darkest chapters in Australia’s medical history,” Anthony Albanese told parliament on Wednesday. “To the survivors – we apologise for the pain thalidomide has inflicted on each and […]
The PARP inhibitor olaparib has already shown promise in treating patients with ovarian and breast cancers who have BRCA1 or BRCA2 germline mutations. Now, a study reported in the Journal of Clinical Oncology has found that the drug also shrinks prostate and pancreatic tumors in people who have these mutations. BRCA mutations disable DNA damage […]