In this article, we will discuss Anlotinib (Therapeutic Efficacy-2). So, let’s get started.
A randomized, double-blind, multicenter, placebo-controlled phase II clinical trial was conducted to estimate the safety and efficacy of anlotinib monotherapy for refractory NSCLC in patients who had failed at least
two types of systemic chemotherapy or experienced drug intolerance, revealing the roles of anlotinib as a third-line therapy or beyond in previously treated NSCLC. Overall, 117 patients were enrolled and randomized 1:1 to receive anlotinib (12 mg per day, per os; days 1–14; 21 days per cycle) or placebo. Patients receiving anlotinib had longer PFS than patients receiving placebo (4.8 vs 1.2 months; hazard ratio (HR) = 0.32; 95% confidence interval (CI), 0.20–0.51; P < 0.0001).