Anticancer Drugs Dactinomycin Oncology Pharmacology Physiotherapy

Dactinomycin (Mechanism of Action)

In this article we will discuss Dactinomycin (Mechanism of Action)

In this article, we will discuss Dactinomycin (Mechanism of Action). So, let’s get started.

Mechanism of Action

Generally, the actinomycins exert an inhibitory effect on gram-positive and gram-negative bacteria and on some fungi. However, the toxic properties of the actinomycins (including dactinomycin) in relation to antibacterial activity are such as to preclude their use as antibiotics in the treatment of infectious diseases. Because the actinomycins are cytotoxic, they have an antineoplastic effect which has been demonstrated in experimental animals with various types of tumor implants. This cytotoxic action is the basis for their use in the treatment of certain types of cancer. Dactinomycin is believed to produce its
cytotoxic effects by binding DNA and inhibiting RNA synthesis.

Pharmacokinetics and Metabolism

Results of a study in patients with malignant melanoma indicate that dactinomycin (3H actinomycin D) is minimally metabolized, is concentrated in nucleated cells, and does not penetrate the blood-brain barrier. Approximately 30% of the dose was recovered in urine and feces in one week. The terminal plasma half-life for radioactivity was approximately 36 hours

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