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Anticancer Drugs Dinutuximab Medicine Oncology Pharmacology Physiotherapy

Dinutuximab

In this article we will discuss Dinutuximab (Dosage Overview)

In this article, we will discuss Dinutuximab (Dosage Overview). So, let’s get started.

Indications

Dinutuximab is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2) and 13-cis-retinoic acid (RA), for the treatment of
pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy.

Dosage

• Verify that patients have adequate hematologic, respiratory, hepatic, and renal function prior to initiating each course of Dinutuximab.
• Administer required premedication and hydration prior to initiation of each Unituxin infusion.

Recommended Dose

The recommended dose of Unituxin is 17.5 mg/m2/day administered as an intravenous
infusion over 10 to 20 hours for 4 consecutive days for a maximum of 5 cycles.

Initiate at an infusion rate of 0.875 mg/m2/hour for 30 minutes. The infusion rate can be gradually increased as tolerated to a maximum rate of 1.75 mg/m2/hour.

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