In this article, we will discuss various Symptoms of the Novel Coronavirus infection.
In this article, we will discuss the Classification of Myocardial Infarction (MI).
In this article, we will discuss about Tension Pneumothorax
In this article, we will discuss about the Clinical features of Pneumothorax.
In this article we will discuss about the various signs and symptoms of Pleural effusion.
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Causes of Orthopnea
In this article we will discuss about the various causes of orthopnea.
Pain and weakness around shoulder joint
Drug Clinical Trial Failures and Risks Explained Drug development follows a complex path.Moreover.It demands high investment and time. Despite promising early data.Many drug candidates still fail. First, Understand the High Failure Rate Most experimental drugs never reach approval.In fact.Failure can happen at any trial stage. Early trials often fail due to safety concerns.Later stages fail […]
Cytochrome P450 Interactions Explained Cytochrome P450 enzymes play a vital role in the body.In particular, they help metabolise drugs in the liver. These enzymes are commonly called CYP enzymes.For example, CYP3A4 and CYP2D6 are well known. Most medicines rely on CYP enzymes for breakdown.As a result, drug levels in the body are regulated. However, problems […]
Sodium Channel Blockers for Pain: Nav1.7 Inhibitors Explained Pain signals travel through nerves.These signals depend on sodium channels.One key channel is called Nav1.7. Nav1.7 is found in peripheral sensory nerves.It plays a major role in pain transmission.When Nav1.7 is overactive, pain increases. Scientists discovered something important.People born without Nav1.7 function feel no pain.They can sense […]
Enterovirus D68 Outbreaks and Respiratory Disease Enterovirus D68 is a non-polio enterovirus.It primarily affects the respiratory system.The virus spreads through respiratory droplets. Most infections occur in children.However, adults can also be affected.Severe illness is more common in children with asthma. Outbreaks are often seasonal.They usually peak in late summer and autumn.Schools and childcare settings aid […]
Crisugabalin: A New Direction in Pain Treatment Crisugabalin is an investigational pain-relief drug.It belongs to the gabapentinoid class.It is related to pregabalin and gabapentin. But it is not the same.Crisugabalin was designed to act more selectively.The goal is better pain control with fewer side effects. What Is Crisugabalin Crisugabalin is also known as Mirogabalin-like gabapentinoid […]
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Phase I Dose-Escalation Studies
Phase I dose-escalation studies are the first step in human trials.They usually involve a small number of participants.Most are conducted in patients, especially in cancer research. The main goal is safety.Researchers aim to find a safe dose range.Efficacy is not the primary focus. Dose escalation is done gradually.Patients receive increasing doses in cohorts.Careful monitoring follows […]