Amyloid-Beta Oligomer Toxicity Mechanisms Amyloid-beta (Aβ) oligomers are widely regarded as the most toxic species in Alzheimer’s disease pathogenesis. Unlike mature amyloid plaques, soluble oligomers appear early, diffuse through tissue, and disrupt neuronal function at low concentrations. Researchers focus on these intermediate assemblies because they correlate more strongly with cognitive decline than plaque burden. 1. […]
Spatial and Temporal Analysis of Tobacco-Related Cancers in High-Burden Regions of India Tobacco-related cancers form a major public health challenge in India. These cancers include oral cavity, lung, esophagus, larynx, and pharynx malignancies. High-burden regions show clear geographic clustering and changing patterns over time. Several states report elevated incidence rates. The Northeast region consistently records […]
Role of Cancer-Associated Fibroblasts and Extracellular Matrix Remodeling in Promoting Therapy Resistance: Integrated Molecular and Histopathological Analysis Cancer-associated fibroblasts play a central role in the tumor microenvironment. These cells actively support tumor growth and progression. At the same time, they remodel the extracellular matrix. This remodeling creates physical and biochemical barriers that limit drug delivery. […]
Intégration de la radiomique et des données génomiques pour prédire les résultats des traitements La radiomique analyse les images médicales. Elle extrait de nombreuses caractéristiques quantitatives. Parallèlement, la génomique étudie les altérations moléculaires des tumeurs. Aujourd’hui, les chercheurs combinent ces deux approches. Cette intégration améliore la prédiction des résultats thérapeutiques. Elle concerne surtout les tumeurs […]
Biomarqueurs prédictifs de réponse et de résistance à la chimiothérapie à base de pémétrexed dans le mésothéliome pleural Le mésothéliome pleural malin reste un cancer agressif. Le pémétrexed associé à un sel de platine constitue depuis longtemps un traitement standard. Cependant, la réponse à cette chimiothérapie varie fortement selon les patients. Identifier des biomarqueurs prédictifs […]
Molecular Glues as a New Modality: Case Studies in Cereblon-Based Degraders for Hematologic Cancers Molecular glues represent an emerging class of therapeutic agents. These small molecules stabilize interactions between proteins. In doing so, they often trigger the degradation of disease-relevant targets. Unlike traditional inhibitors, molecular glues do not simply block protein function. Instead, they promote […]