Treatment of Multiple Myeloma

In this article we will discuss about the Treatment of Multiple Myeloma. So let’s get started.

Treatment

Drug therapy for Multiple Myeloma include

Chemo drugs like Melphalan, Cyclophosphamide, Vincristine etc

Corticosteroids like Dexamethasone etc

Immunomodulating agents like Thalidomide,Lenlidomide etc

Proteasome Inhibitors like Bortezomib,Carfilzomib etc

Histone deacetylase inhibitors like Panobinostat.

Monoclonal antibodies like Daratumumab,Elotuzumab.

Medical management of primary induction therapy in patients with multiple myeloma National Comprehensive Cancer Network recommend following combinations of Proteasome Inhibitors,Immunomodulating agents or Chemotherapeutic drugs and Corticosteroids :-

Bortezomib/lenalidomide/dexamethasone

Bortezomib/cyclophosphamide/dexamethasone

Other drug combinations include

lenalidomide/dexamethasone

Carfilzomib/lenalidomide/dexamethasone

Panobinostat/bortezomib/dexamethasone

Elotuzumab/bortezomib/dexamethasone

Vincristine/doxorubicin/dexamethasone

Melphalan/prednisone with or without thalidomide or bortezomib

Dexamethasone/cyclophosphamide/etoposide/cisplatin

Dexamethasone/thalidomide/cisplatin/doxorubicin/cyclophosphamide/etoposide with or without bortezomib

Biphosphonates are used for associated bone diseases

Adjunct Therapy include

Surgical Intervention

Plasmapheresis

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Sign and Symptoms of Multiple Myeloma

In this article we will discuss about the Sign and Symptoms of Multiple Myeloma. So let’s get started.

Sign and Symptoms

Bone Pain

Pathological Fractures

Infection

Fatigue

Malaise

Bruising

Bleeding

Pain in back and thorax

Swelling in legs

Kidney damage

Hypercalcaemia

Confusion

Dizzness

Neuropathies

Spinal Cord Compression

Shortness of Breathe

Increased Thirst and Urination

Weight loss and Nausea

Constipation