Differential Diagnosis of Aplastic Anemia

In this article, we will discuss Differential Diagnosis of Aplastic Anemia. So, let’s get started.

Differential Diagnosis

Aplastic anemia should be differentiated from other conditions producing pancytopenia such as:

1. Subleukemic or aleukemic leukemia

2. Myelodysplastic syndrome

3. Hypersplenism (e.g. portal hypertension, infiltrative splenomegaly)

4. Bone marrow infiltration (carcinoma, myelofibrosis)

5. Megaloblastic anemia

6. Osteoporosis (marble bone disease)

7. Systemic lupus erythematosus

8. Paroxysmal nocturnal hemoglobinuria

9. Disseminated tuberculosis

10. Overwhelming infection


Clinical Features of Acute Hemolytic Crisis

In this article, we will discuss the Clinical Features of Acute Hemolytic Crisis. So, let’s get started.

Clinical Features

Symptoms: Pallor, weakness, dyspnea, tachycardia, fatigue, abdominal pain

Jaundice (scleral icterus i.e. yellowness of eyes)

Dark color of urine and faeces

Splenomegaly (recent appearance or sudden increase in pre-existing splenomegaly)


Signs: Anemia, jaundice