Clinical Features of Acute Hemolytic Crisis

In this article, we will discuss the Clinical Features of Acute Hemolytic Crisis. So, let’s get started.

Clinical Features

Symptoms: Pallor, weakness, dyspnea, tachycardia, fatigue, abdominal pain

Jaundice (scleral icterus i.e. yellowness of eyes)

Dark color of urine and faeces

Splenomegaly (recent appearance or sudden increase in pre-existing splenomegaly)

Hepatomegaly

Signs: Anemia, jaundice

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Symptoms of hemolytic anemia

In this article we will discuss about the symptoms of hemolytic anemia. So, let’s get started.

Symptoms

Fatigue and weakness

Back pain

Fever

Pale (yellowish) discoloration of skin and mouth

Icteric sclera (yellowish discoloration of eyes)

Dizziness

Confusion

Tachycardia

Dyspnea

Angina

Abdominal pain post development of gallstones due to persistent hemolysis

Leg ulcers

Dark urine

Causes of hemolytic anemia

In this article, we will discuss about the various causes of hemolytic anemia. So, let’s get started.

Causes

Inherited diseases such as thalassemia, sickle cell anemia, G6PD deficiency, hereditary spherocytosis and elliptocytosis, congenital dyserythropoietic anemia, pyruvate kinase deficiency, and paroxysmal nocturnal hemoglobinuria.

Autoimmune causes such as SLE, scleroderma, Hodgkin’s disease, ulcerative colitis, chronic lymphocytic leukemia, rheumatoid arthritis.

Burns

Infections such as mycoplasma pneumonia, malaria, etc.

Certain drugs such as cephalosporin, dapsone, levodopa, levofloxacin, snake or spider venom or lead, arsine or stibine poisoning.

Enlarged or hyperfunctioning spleen

Advanced liver or kidney disease.

Prosthetic heart valve, vascular grafts recipients, cancer, exposure to certain chemicals or clotting disorders.

Footstrike hemolysis in runners.