Amsacrine Anticancer Drugs Oncology Pharmacology Physiotherapy

Amsacrine (Experimental Notes-2)

In this article we will discuss Amsacrine (Experimental Notes-2)

In this article, we will discuss Amsacrine (Experimental Notes-2). So, let’s get started.

The bioavailability of orally administered amsacrine in mice (10 mg/kg bw) and
rats (100 mg/kg bw) was incomplete and variable (Cysyk et al., 1978), with high
concentrations occurring in the liver and rapid excretion into the bile. In rabbits, the
bioavailability of amsacrine given orally at a dose of 12.7 ╬╝mol/kg bw was 50% in fed
animals but 90% in fasting rabbits (Paxton, 1986)

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