In this article, we will discuss Amsacrine (Experimental Notes-2). So, let’s get started.
The bioavailability of orally administered amsacrine in mice (10 mg/kg bw) and
rats (100 mg/kg bw) was incomplete and variable (Cysyk et al., 1978), with high
concentrations occurring in the liver and rapid excretion into the bile. In rabbits, the
bioavailability of amsacrine given orally at a dose of 12.7 μmol/kg bw was 50% in fed
animals but 90% in fasting rabbits (Paxton, 1986)