Amsacrine (Experimental Notes-3)

After intravenous administration of amsacrine to mice and rats, > 50% of the radiolabel was excreted in bile within the first 2 h, and the bile:plasma ratio was > 400:1 (Cysyk et al., 1977); 74% of an intravenous dose was excreted in the faeces of mice within 72 h (Robertson et al., 1988). These studies demonstrate the importance of the liver in clearance of amsacrine