In this article, we will discuss Amsacrine (Experimental Notes-1). So, let’s get started.
The pharmacokinetics of amsacrine has been described for mice (Cysyk et al., 1977;
Kestell et al., 1990), rats (Cysyk et al., 1977), rabbits (Paxton & Jurlina, 1985) and dogs
(Paxton et al., 1990). This typically includes biphasic elimination, with a rapid
distribution phase and a more prolonged terminal elimination phase with a half-time of about 0.2 h in mice, 0.5 h in rats, 2.6 h in rabbits and 6.5 h in dogs. The pharmacokinetics was typically predictable in all species, including humans (Paxton et al., 1990).