In this article, we will discuss Amsacrine (Oncology-6). So, let’s get started.
About 97% of a dose of amsacrine is bound to protein bound in plasma in both
cancer patients and healthy volunteers. Studies of human plasma in vitro showed no change in protein binding across a concentration range of 1–100 μmol/L. The unbound fraction increased to 21.7%, however, when the pH was changed to 6.4 (Paxton et al.,1986). No studies of the metabolism of amsacrine in humans have been published.