In this article, we will discuss Amsacrine (Genetics and Related Effects-3). So, let’s get started.
Amsacrine reverted a frameshift mutant of T4 and induced prophage λ in Escheri-
chia coli WP2, suggesting an ‘SOS’ repair response. In Saccharomyces cerevisiae strain D5, amsacrine failed to induce the mitochondrial ‘petite’ mutation, but it was an effective mitotic recombinogen when testing was done under conditions permitting cell growth. It did not induce either forward or reverse mutations in Neurospora crassa.