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Amsacrine Anticancer Drugs Oncology Pharmacology Physiotherapy

Amsacrine (Oncology-1)

In this article we will discuss Amsacrine (Oncology-1)

In this article, we will discuss Amsacrine (Oncology-1). So, let’s get started.

Humans

In cancer patients, amsacrine undergoes biphasic elimination, with a distribution
half-time of 0.25–1.6 h (Van Echo et al., 1979; Jurlina et al., 1985; Linssen et al., 1993) and an elimination half-time of 4.7–9 h (Van Echo et al., 1979; Hall et al., 1983; Jurlina et al., 1985; Linssen et al., 1993). The total plasma clearance rate is 200–300 mL/min per m2, and the apparent distribution volume is 70–110 L/m2, suggesting concentration in tissues (Jurlina et al., 1985; Linssen et al., 1993). During a 1-h infusion of amsacrine at 90–200 mg/m2, the peak plasma concentration was 10–15 μmol/L (Van Echo et al., 1979; Jurlina et al., 1985).

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