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Amsacrine Anticancer Drugs Oncology Pharmacology Physiotherapy

Amsacrine (Genetics and Related Effects-2)

In this article we will discuss Amsacrine (Genetics and Related Effects-2)

In this article, we will discuss Amsacrine (Genetics and Related Effects-2). So, let’s get started.

Amsacrine was mutagenic in some strains of Salmonella typhimurium, causing an
increased number of revertants in TA1537, a small increase (about twofold) in revertants in TA102 but no increase in revertants in TA1535, TA98 or TA100. Addition of an exogenous metabolic system reduced but did not eliminate the mutagenic effects in TA1537. The positive effects required a dose of about 800 μg/plate, which is higher than those tested in mammalian cells.

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