Bleomycin (Mechanism of Action)

In this article, we will discuss Bleomycin (Mechanism of Action). So, let’s get started.

Mechanism of Action

Although the exact mechanism of action of Bleomycin is unknown, available
evidence indicates that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis.

Bleomycin is known to cause single, and to a lesser extent, double-stranded breaks in
DNA. In in vitro and in vivo experiments, bleomycin has been shown to cause cell cycle arrest in G2 and in mitosis.

When administered into the pleural cavity in the treatment of malignant pleural effusion, Bleomycin acts as a sclerosing agent.

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