In this article, we will discuss Mesna (Dosage Overview). So, let’s get started.
Indications
Mesna is indicated as a prophylactic agent in reducing the incidence of ifosfamide-induced hemorrhagic cystitis.
Limitation of Use:
Mesna is not indicated to reduce the risk of hematuria due to other pathological conditions such as thrombocytopenia.
Dosage
Intravenous Dosing
Mesna may be given on a fractionated dosing schedule of three bolus intravenous injections as outlined below.
Mesna injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage weight by weight (w/w) at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide. The total daily dose of Mesna is 60% of the ifosfamide dose. The recommended dosing schedule is outlined below in Table 1.
Intravenous and Oral Dosing
Mesna may be given on a fractionated dosing schedule of a single bolus injection followed by two oral administrations of MESNEX tablets as outlined below.
Mesna injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage (w/w) at the time of ifosfamide administration. Mesna tablets are given orally in a dosage equal to 40% of
the ifosfamide dose 2 and 6 hours after each dose of ifosfamide. The total daily dose of Mesna is 100% of the ifosfamide dose. The recommended dosing schedule is outlined in Table 2.
The efficacy and safety of this ratio of intravenous and oral Mesna has not been established as being effective for daily doses of ifosfamide higher than 2 g/m².
Patients who vomit within two hours of taking oral Mesna should repeat the dose or receive intravenous Mesna.