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Anticancer Drugs Bleomycin Medicine Oncology Pharmacology Physiotherapy

Bleomycin

In this article we will discuss Bleomycin (Dosage Overview)

In this article, we will discuss Bleomycin (Dosage Overview). So, let’s get started.

Dosage

Because of the possibility of an anaphylactoid reaction, lymphoma patients should be treated with 2 units or less for the first 2 doses. If no acute reaction occurs, then the regular dosage schedule may be followed.

The following dose schedule is recommended:

Squamous cell carcinoma, non-Hodgkin’s lymphoma, testicular carcinoma—0.25 to
0.50 units/kg (10 to 20 units/m²) given intravenously, intramuscularly, or subcutaneously weekly or twice weekly.

Hodgkin’s disease—0.25 to 0.50 units/kg (10 to 20 units/m²) given intravenously,
intramuscularly, or subcutaneously weekly or twice weekly. After a 50% response, a
maintenance dose of 1 unit daily or 5 units weekly intravenously or intramuscularly
should be given.

Pulmonary toxicity of Bleomycin appears to be dose-related with a striking increase
when the total dose is over 400 units. Total doses over 400 units should be given with
great caution.

Note: When Bleomycin is used in combination with other antineoplastic agents, pulmonary toxicities may occur at lower doses.

Improvement of Hodgkin’s disease and testicular tumors is prompt and noted within 2 weeks. If no improvement is seen by this time, improvement is unlikely. Squamous cell cancers respond more slowly, sometimes requiring as long as 3 weeks before any improvement is noted.

Malignant Pleural Effusion—60 units administered as a single dose bolus intrapleural injection.

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