Anticancer Drugs Octreotide Oncology Pharmacology Physiotherapy

Octreotide (Mechanism of Action)

In this article we will discuss Octreotide
(Mechanism of Action)

In this article, we will discuss Octreotide (Mechanism of Action). So, let’s get started.

Mechanism of Action

Octreotide exerts pharmacologic actions similar to the natural hormone, somatostatin. It is an even more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Like somatostatin, it also suppresses LH response to GnRH, decreases splanchnic blood flow, and inhibits release of serotonin, gastrin, vasoactive intestinal peptide, secretin, motilin, and pancreatic polypeptide. By virtue of these pharmacological actions, octreotide has been used to treat the symptoms associated with metastatic carcinoid tumors (flushing and
diarrhea), and Vasoactive Intestinal Peptide (VIP) secreting adenomas (watery diarrhea).


Octreotide substantially reduces and in many cases can normalize growth hormone and/or IGF-1 (somatomedin C) levels in patients with acromegaly. Single doses of Octreotide Injection given subcutaneously have been shown to inhibit gallbladder contractility and to decrease bile secretion in normal volunteers. In controlled clinical trials the incidence of gallstone or biliary sludge formation was markedly increased. Octreotide may cause clinically significant suppression of thyroid stimulating hormone (TSH).

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