Hepatotoxicity and Ceritinib (3)
Clinical Management:
• Monitoring: Regular monitoring of liver function tests (LFTs) is recommended for patients on ceritinib. This typically includes tests for ALT, AST, alkaline phosphatase, and bilirubin levels.
• Dose Adjustments: Depending on the severity of hepatotoxicity, dose adjustments, interruptions, or discontinuation of ceritinib may be necessary. Guidelines suggest specific thresholds for modifying the treatment based on the levels of liver enzymes and symptoms of liver dysfunction.