In this article we will discuss Anlotinib (Background-2). So, let’s get started.
RTK activity is regulated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Normal tissues show no or low activity and expression of most oncogenic RTKs, while many malignant cells show hyperactive RTKs or upregulated oncogenic RTK levels. Downregulation of PTK activity can attenuate tumor cell growth, angiogenesis, and anti-apoptotic effects.