In this article, we will discuss Amsacrine (Oncology-4). So, let’s get started.
Amsacrine is taken up rapidly by nucleated blood cells in vivo, peak concentrations occurring shortly after the end of a 3-h infusion; the concentration was about five times greater than the peak plasma concentration. Over 24 h, the mean integrated area under the time–concentration curve (AUC) for cellular amsacrine was eight times that of the AUC for plasma. The kinetics of elimination from peripheral blast cells was similar to that from plasma (Linssen et al., 1993).