In this article, we will discuss Amsacrine (Toxic Effects in Humans- 1). So, let’s get started.
Toxic effects in Humans
The toxicity of amsacrine in humans has been comprehensively reviewed and
summarized (Hornedo & Van Echo, 1985; Louie & Issell, 1985). In all of the phase I
studies, the dose-limiting toxic effect was myelosuppression, resulting mainly in leukopenia. Other effects included nausea, vomiting, fever, injection-site reaction, skin rash and discolouration (due to the yellow colour of the drug), mucositis and alopecia. Paraesthesia and hepatoxicity were seen in a few patients, but cardiac toxicity was not observed in one study (Louie & Issell, 1985).