Amsacrine Anticancer Drugs Oncology Pharmacology Physiotherapy

Amsacrine (Intraperitoneal Administration)

In this article we will discuss Amsacrine (Intraperitoneal Administration)

In this article, we will discuss Amsacrine (Intraperitoneal Administration). So, let’s get started.

Intraperitoneal Administration

Mouse: In a bioassay for lung tumours, groups of 26 male and 26 female A/J mice,
six to eight weeks of age, received seven weekly intraperitoneal injections of amsacrine [purity unspecified] in dimethyl sulfoxide and tricaprylin at a dose of 0 (vehicle control), 2, 5 or 10 mg/kg bw. Positive controls received a single intraperitoneal injection of 500 or 1000 mg/kg bw urethane. The mice were held for 17 weeks after the last injection. In
the groups treated with amsacrine, no significant increase in the number of mice with lung adenomas was observed [tumour incidence and multiplicity not reported] (de la Iglesia et al., 1984).

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