In this article, we will discuss Amsacrine (Intraperitoneal Administration). So, let’s get started.
Mouse: In a bioassay for lung tumours, groups of 26 male and 26 female A/J mice,
six to eight weeks of age, received seven weekly intraperitoneal injections of amsacrine [purity unspecified] in dimethyl sulfoxide and tricaprylin at a dose of 0 (vehicle control), 2, 5 or 10 mg/kg bw. Positive controls received a single intraperitoneal injection of 500 or 1000 mg/kg bw urethane. The mice were held for 17 weeks after the last injection. In
the groups treated with amsacrine, no significant increase in the number of mice with lung adenomas was observed [tumour incidence and multiplicity not reported] (de la Iglesia et al., 1984).