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Anticancer Drugs Oncology Pharmacology Physiotherapy

Vismodegib and Animal Toxicology

In this article we will discuss Vismodegib and Animal Toxicology

In this article, we will discuss Vismodegib and Animal Toxicology. So, let’s get started.

Animal Toxicology

Neurologic effects characterized as limb or body tremors or twitching were observed in rats administered oral vismodegib for 4 weeks or longer at 50 mg/kg/day (approximately 0.4 times the AUC in patients at the recommended human dose). These observations resolved upon discontinuation of dosing and were not associated with microscopic findings.

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