In this article, we will discuss Bleomycin (Excretion). So, let’s get started.
Bleomycin (Excretion)
The primary route of elimination is via the kidneys. About 65% of the administered
intravenous dose is excreted in urine within 24 hours. In patients with normal renal
function, plasma concentrations of bleomycin decline biexponentially with a mean terminal half-life of 2 hours following intravenous bolus administration. Total body clearance and renal clearance averaged 51 mL/min/m2 and 23 mL/min/m2 , respectively. Following intrapleural administration to patients with normal renal function, a lower percentage of drug (40%) is recovered in the urine, as compared to that found in the urine after intravenous administration.