In this article, we will discuss Sulindac and Ankylosing Spondylitis. So, let’s get started.
Sulindac and Ankylosing spondylitis
In patients with ankylosing spondylitis, the anti-inflammatory and analgesic activity of Sulindac was demonstrated by clinical measurements that included: assessments by both patient and investigator of overall response; decrease in disease activity as assessed by both patient and investigator; improvement in ARA Functional Class; improvement in patient and investigator evaluation of spinal pain, tenderness
and/or spasm; reduction in the duration of morning stiffness; increase in the time to onset of fatigue; relief of night pain; increase in chest expansion; and increase in spinal mobility evaluated by fingers-to-floor distance, occiput to wall distance, the Schober Test, and the Wright Modification of the Schober Test. In a clinical study in which dosages were adjusted according to patient need, Sulindac 200 to 400 mg daily
was as effective as indomethacin 75 to 150 mg daily. In a second study, Sulindac 300 to 400 mg daily was comparable in effectiveness to phenylbutazone 400 to 600 mg daily. Sulindac was better tolerated than phenylbutazone.