Pharmacology Physiotherapy Sulindac

Sulindac and Ankylosing Spondylitis

In this article we will discuss Sulindac and Ankylosing Spondylitis

In this article, we will discuss Sulindac and Ankylosing Spondylitis. So, let’s get started.

Sulindac and Ankylosing spondylitis

In patients with ankylosing spondylitis, the anti-inflammatory and analgesic activity of Sulindac was demonstrated by clinical measurements that included: assessments by both patient and investigator of overall response; decrease in disease activity as assessed by both patient and investigator; improvement in ARA Functional Class; improvement in patient and investigator evaluation of spinal pain, tenderness
and/or spasm; reduction in the duration of morning stiffness; increase in the time to onset of fatigue; relief of night pain; increase in chest expansion; and increase in spinal mobility evaluated by fingers-to-floor distance, occiput to wall distance, the Schober Test, and the Wright Modification of the Schober Test. In a clinical study in which dosages were adjusted according to patient need, Sulindac 200 to 400 mg daily
was as effective as indomethacin 75 to 150 mg daily. In a second study, Sulindac 300 to 400 mg daily was comparable in effectiveness to phenylbutazone 400 to 600 mg daily. Sulindac was better tolerated than phenylbutazone.

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