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Anticancer Drugs Oncology Palonosetron Pharmacology Physiotherapy

Palonosetron (Elimination)

In this article we will discuss Palonosetron (Elimination)

In this article, we will discuss Palonosetron (Elimination). So, let’s get started.

Palonosetron (Elimination)

After a single intravenous dose of 10 mcg/kg [14C]-palonosetron HCl, approximately
80% of the dose was recovered within 144 hours in the urine with palonosetron
representing approximately 40% of the administered dose. In healthy subjects, the total body clearance of palonosetron was 0.160 ± 0.035 L/h/kg and renal clearance was 0.067 ± .018 L/h/kg. The mean terminal elimination half-life is approximately 40 hours.

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