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Anticancer Drugs Oncology Palonosetron Pharmacology Physiotherapy

Palonosetron (Metabolism)

In this article we will discuss Palonosetron (Metabolism)

In this article, we will discuss Palonosetron (Metabolism). So, let’s get started.

Palonosetron (Metabolism)

Palonosetron is eliminated by multiple routes with approximately 50% metabolized to form two primary metabolites: N-oxide-palonosetron and 6-S-hydroxy-palonosetron. These metabolites each have less than 1% of the 5-HT3 receptor antagonist activity of palonosetron. In vitro metabolism studies have suggested that CYP2D6 and to a lesser extent, CYP3A4 and CYP1A2 are involved in the metabolism of palonosetron. However, clinical pharmacokinetic parameters are not significantly different between poor and
extensive metabolizers of CYP2D6 substrates.

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