Anticancer Drugs Oncology Palifermin Pharmacology Physiotherapy

Palifermin and Proteinuria

In this article we will discuss Palifermin and Proteinuria

In this article, we will discuss Palifermin and Proteinuria. So, let’s get started.

Palifermin and Proteinuria

In a placebo-controlled study conducted in 145 patients with metastatic
colorectal cancer receiving multi-cycle chemotherapy (5-FU/lecovorin), serial urine specimens were collected for 27 placebo-treated and 54 palifermin-treated patients.

Among the 54 palifermin-treated patients, nine patients with a baseline urinalysis
negative for protein subsequently developed 2+ or greater proteinuria after treatment with palifermin. Among the 27 placebo-treated patients evaluated, none developed 2+ or greater proteinuria. Because of the study design, the number of cycles with urine analysis data collected was higher in the palifermin- treated patients. In addition, for the 9 patients with proteinuria, underlying medical conditions known to be associated with proteinuria were present at baseline. A causal relationship between palifermin and proteinuria has not been established.

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