In this article, we will discuss Hydroxyurea (Dosage Overview). So, let’s get started.
Hydroxyurea is indicated for the treatment of:
• Resistant chronic myeloid leukemia.
• Locally advanced squamous cell carcinomas of the head and neck (excluding the lip) in combination with chemoradiation.
Hydroxyurea is used alone or in conjunction with other antitumor agents or radiation therapy to treat neoplastic diseases. Individualize treatment based on tumor type, disease state, response to treatment, patient risk factors, and current clinical practice standards. Base all dosage on the patient’s actual or ideal weight, whichever is less.
Hydroxyurea is a cytotoxic drug. Follow applicable special handling and disposal procedures.
Prophylactic administration of folic acid is recommended.
Dose Modifications for Toxicity
Monitor for the following and reduce the dose or discontinue Hydroxyurea accordingly:
• Cutaneous vasculitis
Monitor blood counts at least once a week during Hydroxyurea therapy. Severe anemia must be corrected before initiating therapy with Hydroxyurea. Consider dose modifications for other toxicities.
Dose Modifications for Renal Impairment
Reduce the dose of Hydroxyurea by 50% in patients with measured creatinine clearance of less than 60 mL/min or with end-stage renal disease (ESRD).
Creatinine Clearance (mL/min) – Recommended HYDREA Initial Dose
• >60 – 15
• <60 or ESRD – 7.5
* On dialysis days, administer Hydroxyurea to patients following hemodialysis.