Arsenic Trioxide (Mechanism of Action)

In this article, we will discuss Arsenic Trioxide (Mechanism of Action). So, let’s get started.

Mechanism of Action

The mechanism of action of Arsenic Trioxide is not completely understood. Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in
vitro. Arsenic trioxide also causes damage or degradation of the fusion protein promyelocytic leukemia (PML)­ retinoic acid receptor (RAR)-alpha.

Pharmacodynamics

Cardiac Electrophysiology
A dedicated QTc study was not performed with Trisenox. However, in a single arm trial of Arsenic Trioxide (0.15 mg/kg daily), 16 of 40 patients (40%) had a QTc interval greater than 500 msec. Prolongation of the QTc was
observed between 1 and 5 weeks after Arsenic Trioxide infusion, and then returned towards baseline by the end of 8 weeks after Arsenic Trioxide infusion.

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