In this article, we will discuss Palonosetron (Dosage Overview). So, let’s get started.
Dosage for Adults
The recommended dosage of palonosetron is 0.25 mg administered as a single dose approximately 30 minutes before the start of chemotherapy. Repeated dosing of palonosetron within a seven day interval is not recommended because the safety and efficacy of frequent (consecutive or alternate day) dosing in patients has not been evaluated.
Use in Geriatric Patients and in Patients with Impaired Renal or Hepatic Function
No dosage adjustment is recommended.
Dosage for Pediatric Patients
A recommended intravenous dosage has not been established for pediatric patients.
Administration
Palonosetron is to be infused intravenously over 30 seconds. Palonosetron should not be mixed with other drugs.
Flush the infusion line with normal saline before and after administration of palonosetron.
Stability
Parenteral drug products should be inspected visually for particulate matter and discoloration before administration, whenever solution and container permit.