Decitabine

In this article, we will discuss Decitabine (Dosage Overview). So, let’s get started.

Indications

Decitabine is indicated for treatment of adult patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups.

Dosage

Recommended Starting Dosage

Pre-Medications and Baseline Testing

Consider pre-medicating for nausea with antiemetics.

Conduct baseline laboratory testing: CBC with platelets, serum hepatic panel, and serum creatinine.

Decitabine Regimen Options

Three Day Regimen

Administer decitabine at a dose of 15 mg/m2 by continuous intravenous infusion over 3 hours repeated every 8 hours for 3 days. Repeat cycles every 6 weeks upon hematologic recovery (ANC at least 1,000/µL and platelets at least 50,000/µL) for a minimum of 4 cycles. . A complete or partial response may take longer than 4 cycles. Delay and reduce dose for hematologic toxicity.

Five Day Regimen

Administer decitabine at a dose of 20 mg/m2 by continuous intravenous infusion over 1 hour daily for 5 days. Delay and reduce dose for hematologic toxicity. Repeat cycles every 4 weeks upon hematologic recovery (ANC at least 1,000/µL and platelets at least 50,000/µL) for a minimum of 4 cycles. A complete or partial response may take
longer than 4 cycles.

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