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Hematology Medicine Physiotherapy Thrombotic Thrombocytopenic Purpura

Diagnosis of Thrombotic Thrombocytopenic Purpura

In this article we will discuss the Diagnosis of Thrombotic Thrombocytopenic Purpura.

In this article, we will discuss the Diagnosis of Thrombotic Thrombocytopenic Purpura. So, let’s get started.

Investigations/Diagnosis

  • Hemoglobin level is low
  • Platelet count is low
  • PBF shows fragmented RBCs or schistocytes- a pathognomonic finding. Reticulocyte count is raised.
  • Test for hemolysis: Serum LDH levels are raised due to intravascular hemolysis. Hemoglobinuria may be present. There is raised indirect bilirubin. Haptoglobin levels are reduced. Direct Coomb’s test is negative.
  • Test for coagulation such as PT, PTT, fibrinogen level and fibrin split products are usually normal or only midly abnormal.
  • Reduction in vWPCP activity
  • Tissue Biopsy: Biopsies of skin, muscles, gingiva, lymph node may demonstrate fibrin thrombi within arterioles
  • Bone marrow may be hypocellular.

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