Diagnosis of Thrombotic Thrombocytopenic Purpura

In this article, we will discuss the Diagnosis of Thrombotic Thrombocytopenic Purpura. So, let’s get started.

Investigations/Diagnosis

  • Hemoglobin level is low
  • Platelet count is low
  • PBF shows fragmented RBCs or schistocytes- a pathognomonic finding. Reticulocyte count is raised.
  • Test for hemolysis: Serum LDH levels are raised due to intravascular hemolysis. Hemoglobinuria may be present. There is raised indirect bilirubin. Haptoglobin levels are reduced. Direct Coomb’s test is negative.
  • Test for coagulation such as PT, PTT, fibrinogen level and fibrin split products are usually normal or only midly abnormal.
  • Reduction in vWPCP activity
  • Tissue Biopsy: Biopsies of skin, muscles, gingiva, lymph node may demonstrate fibrin thrombi within arterioles
  • Bone marrow may be hypocellular.
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