Topotecans (Drug Interactions)
Here are some examples of drug interactions that can occur with topotecan:
Other Chemotherapies:
- Cyclophosphamide: Combining topotecan with cyclophosphamide can increase the risk of bleeding.
- Taxanes: Using topotecan with taxanes (such as paclitaxel or docetaxel) can increase the risk of nerve damage.
Antibiotics:
Fluoroquinolones: Taking topotecan with fluoroquinolones (such as ciprofloxacin or levofloxacin) can increase the risk of heart problems.
Blood Thinners:
Warfarin: Using topotecan with warfarin can increase the risk of bleeding.
Other Medications:
- Potassium-lowering medications: Taking topotecan with medications that lower potassium levels (such as diuretics) can increase the risk of heart problems.
- Grapefruit juice: Consuming grapefruit juice while taking topotecan can increase the blood levels of the drug, potentially leading to side effects.