In this article, we will discuss Olaparib (Drug Interaction-3). So, let’s get started.
Drugs That May Increase Olaparib Plasma Concentrations
Olaparib is primarily metabolized by CYP3A. In patients (n=57), co-administration of itraconazole, a strong CYP3A inhibitor, increased AUC of olaparib by 170%. A moderate CYP3A inhibitor, fluconazole, is predicted to increase the AUC of olaparib by 121%.