In this article, we will discuss Olaparib (Dose Modifications-1). So, let’s get started.
- Dose Modifications for Use with CYP3A Inhibitors
- Avoid concomitant use of strong or moderate CYP3A inhibitors and consider alternative agents with less CYP3A inhibition. If a strong CYP3A inhibitor must be co-administered, reduce the Olaparib dose to 100 mg (one 100 mg tablet) taken twice daily (equivalent to a total daily dose of 200 mg). If a moderate
CYP3A inhibitor must be co-administered, reduce the Olaparib dose to 150 mg (one 150 mg tablet) taken twice daily (equivalent to a total daily dose of 300 mg)