In this article, we will discuss Anlotinib (Therapeutic Efficacy-4). So, let’s get started.
Considering that anlotinib induced tumors to shrink in soft tissue sarcomas in a phase I study, a multicenter, single-arm, phase II study subsequently explored anlotinib activity in patients with advanced STS who had failed previous conventional treatments. The enrolled patients had malignant fibrous histiocytoma (MFH), liposarcoma, leiomyosarcoma (LMS), synovial sarcoma (SS), or other sarcomas, but not rhabdomyosarcoma (RMS), chondrosarcoma, or GIST STS. Among the 166 patients included, the progression-free rate at week 12 (PFR12w) was 57.23%, median PFS was 5.63 months, and the ORR was 11.45%. Overall, anlotinib demonstrated better clinical benefits in many pathological types of STS. Specifically, alveolar soft part sarcoma (ASPS) showed a high PFR12w (76.92%), similar to the efficacy of sunitinib toward ASPS. The study team further conducted a phase IIB study to demonstrate the role of anlotinib in advanced STS. Overall, 233 patients who were treatment-intolerant or progressed on anthracycline-based chemotherapy were enrolled.