In this article we will discuss Anlotinib (Pharmacokinetics-6). So, let’s get started.
In another phase I study performed in a Caucasian population, the average Tmax and Cmax after a single 12-mg dose of anlotinib were 10 (4–24) h and 9.60 (8.47–11.50) ng/mL, respectively, which were very similar to the values found in the Chinese patients. Following multiple, continuous doses of anlotinib, the average Tmax and Cmax were 360 h and 63.80 (52.90–80.30) ng/mL, respectively. The authors of this phase I study also suggested a dosing regimen of 12 mg daily, 2 weeks on/1 week off for phase II studies.