In this article, we will discuss Anlotinib (Pharmacokinetics-2). So, let’s get started.
In vitro, anlotinib could be metabolized by various human cytochrome P450 isoforms; CYP3A4 and CYP3A5 were mainly responsible. This suggests that circulating anlotinib levels are easily influenced by
hepatic drugs that alter the function of P450 enzymes. In vivo, anlotinib exerted a significant effect on the induction of CYP2D1 and CYP3A 1/2, while it did not have a significant effect on CYP1A2, CYP2D2, or
CYP2C6 after oral administration in rats. Caution, therefore, is warranted when anlotinib is administered with other drugs that are metabolized by CYP2D1 and CYP3A 1/2.