In this article, we will discuss Etoposide (Metabolism). So, let’s get started.
- Metabolism
- Following intravenous administration of Etoposide, etoposide phosphate is completely converted to etoposide in plasma. Etoposide is metabolized by opening of the lactone ring, O-demethylation, and conjugation (i.e., glucuronidation and sulfation). O-demethylation occurs through the CYP450 3A4 isoenzyme pathway to produce the active catechol metabolite