Amsacrine Anticancer Drugs Oncology Pharmacology Physiotherapy

Amsacrine (Technical Products and Impurities)

In this article we will discuss Amsacrine (Technical Products and Impurities)

In this article, we will discuss Amsacrine (Technical Products and Impurities). So, let’s get started.

Technical products and impurities

Three intravenous formulations have been used in clinical studies: amsacrine
lactate, amsacrine lactate plus anhydrous N,N-dimethylacetamide and amsacrine
gluconate (Hornedo & Van Echo, 1985; Louie & Issell, 1985). Amsacrine is formu-
lated as two sterile liquids in separate ampoules, one containing 75 mg of the drug in 1.5 mL N,N-dimethylacetamide, the other containing 13.5 mL of 0.0353 mol/L lactic acid. On mixing, the resulting solution contains 5 mg/mL of amsacrine. Amsacrine is typically used in combination with other antileukaemic agents, including cytarabine, thioguanine, 5-azacytidine, vincristine and prednisone (Gennaro, 1995; Editions du Vidal, 1998; Rote Liste Sekretariat, 1998; Thomas, 1998).

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