In this article, we will discuss Amsacrine (Technical Products and Impurities). So, let’s get started.
Technical products and impurities
Three intravenous formulations have been used in clinical studies: amsacrine
lactate, amsacrine lactate plus anhydrous N,N-dimethylacetamide and amsacrine
gluconate (Hornedo & Van Echo, 1985; Louie & Issell, 1985). Amsacrine is formu-
lated as two sterile liquids in separate ampoules, one containing 75 mg of the drug in 1.5 mL N,N-dimethylacetamide, the other containing 13.5 mL of 0.0353 mol/L lactic acid. On mixing, the resulting solution contains 5 mg/mL of amsacrine. Amsacrine is typically used in combination with other antileukaemic agents, including cytarabine, thioguanine, 5-azacytidine, vincristine and prednisone (Gennaro, 1995; Editions du Vidal, 1998; Rote Liste Sekretariat, 1998; Thomas, 1998).