In this article, we will discuss Bleomycin (Metabolism). So, let’s get started.
Metabolism
Bleomycin is inactivated by a cytosolic cysteine proteinase enzyme, bleomycin
hydrolase. The enzyme is widely distributed in normal tissues with the exception of the
skin and lungs, both targets of bleomycin toxicity. Systemic elimination of the drug by
enzymatic degradation is probably only important in patients with severely compromised renal function.